Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Nelson L Brock; Alexander Nikolay; Jeroen S Dickschat

doi:10.1039/c4cc01924e

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Chem Commun (Camb). 2014 May 28;50(41):5487-9. doi: 10.1039/c4cc01924e.

Authors

Nelson L Brock¹, Alexander Nikolay, Jeroen S Dickschat

Affiliation

¹ Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany. j.dickschat@tu-braunschweig.de.

PMID: 24723119
DOI: 10.1039/c4cc01924e

Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / biosynthesis*
Anti-Bacterial Agents / chemistry
Rhodobacteraceae / metabolism*
Tropolone / analogs & derivatives*
Tropolone / chemistry
Tropolone / metabolism

Substances

Anti-Bacterial Agents
tropodithietic acid
Tropolone