Shigella stands up to the challenge of adhesion

Latéfa Biskri; Abdelmounaaïm Allaoui

doi:10.1016/j.chom.2014.03.009

Shigella stands up to the challenge of adhesion

Cell Host Microbe. 2014 Apr 9;15(4):393-5. doi: 10.1016/j.chom.2014.03.009.

Authors

Latéfa Biskri¹, Abdelmounaaïm Allaoui²

Affiliations

¹ Laboratoire de Bactériologie Moléculaire, Université Libre de Bruxelles (ULB), Faculté de Médecine, 808 Route de Lennik, 1070 Brussels, Belgium.
² Laboratoire de Bactériologie Moléculaire, Université Libre de Bruxelles (ULB), Faculté de Médecine, 808 Route de Lennik, 1070 Brussels, Belgium. Electronic address: aallaoui@ulb.ac.be.

PMID: 24721565
DOI: 10.1016/j.chom.2014.03.009

Abstract

The invasion process of S. flexneri is well characterized, but mechanisms underlying this bacterium's adhesion to host cells have remained obscure. In this issue of Cell Host & Microbe, Brotcke Zumsteg et al. (2014) report a surprising role for the Shigella virulence factor IcsA (VirG) as an adhesin.

Publication types

Comment

MeSH terms

Animals
Bacterial Adhesion / physiology*
Bacterial Proteins / metabolism*
Bacterial Secretion Systems*
DNA-Binding Proteins / metabolism*
Humans
Shigella flexneri / pathogenicity*
Transcription Factors / metabolism*

Substances

Bacterial Proteins
Bacterial Secretion Systems
DNA-Binding Proteins
Transcription Factors
virG protein, Shigella flexneri