Surface microstructure and in vitro analysis of nanostructured akermanite (Ca2MgSi2O7) coating on biodegradable magnesium alloy for biomedical applications

Colloids Surf B Biointerfaces. 2014 May 1:117:432-40. doi: 10.1016/j.colsurfb.2013.12.011. Epub 2013 Dec 12.

Abstract

Magnesium (Mg) alloys, owing to their biodegradability and good mechanical properties, have potential applications as biodegradable orthopedic implants. However, several poor properties including low corrosion resistance, mechanical stability and cytocompatibility have prevented their clinical application, as these properties may result in the sudden failure of the implants during the bone healing. In this research, nanostructured akermanite (Ca2MgSi2O7) powder was coated on the AZ91 Mg alloy through electrophoretic deposition (EPD) assisted micro arc oxidation (MAO) method to modify the properties of the alloy. The surface microstructure of coating, corrosion resistance, mechanical stability and cytocompatibility of the samples were characterized with different techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), electrochemical corrosion test, immersion test, compression test and cell culture test. The results showed that the nanostructured akermanite coating can improve the corrosion resistance, mechanical stability and cytocompatibility of the biodegradable Mg alloy making it a promising material to be used as biodegradable bone implants for orthopedic applications.

Keywords: Akermanite coating; Biodegradable Mg alloy; Corrosion; Cytocompatibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alloys / pharmacology*
  • Animals
  • Biomedical Technology / methods*
  • Cell Survival / drug effects
  • Ceramics / chemistry*
  • Ceramics / pharmacology*
  • Coated Materials, Biocompatible / chemistry
  • Coated Materials, Biocompatible / pharmacology*
  • Compressive Strength / drug effects
  • Dielectric Spectroscopy
  • Electrochemical Techniques
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / ultrastructure
  • Ions
  • Magnesium / pharmacology*
  • Mice
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Oxidation-Reduction / drug effects
  • Surface Properties
  • X-Ray Diffraction

Substances

  • Alloys
  • Coated Materials, Biocompatible
  • Ions
  • Glass ceramics
  • Magnesium