Metabolic features of melanoma: a gold mine of new therapeutic targets?

Curr Cancer Drug Targets. 2014;14(4):357-70. doi: 10.2174/1568009614666140407113124.

Abstract

In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Cell Proliferation / drug effects
  • Enzyme Inhibitors / therapeutic use*
  • Glycolysis / drug effects
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / enzymology
  • Melanoma / metabolism
  • Mitochondria / drug effects
  • Mitochondria / enzymology
  • Mitochondria / metabolism
  • Models, Biological*
  • Molecular Targeted Therapy*
  • Neoplasm Proteins / antagonists & inhibitors*
  • Neoplasm Proteins / metabolism
  • Signal Transduction / drug effects
  • Skin / drug effects
  • Skin / enzymology
  • Skin / metabolism
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / enzymology
  • Skin Neoplasms / metabolism

Substances

  • Amino Acids
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Neoplasm Proteins