High performance conducting polymer nanofiber biosensors for detection of biomolecules

Adv Mater. 2014 Aug 6;26(29):4954-60. doi: 10.1002/adma.201400753. Epub 2014 Apr 9.

Abstract

Sensitive detection and selective determination of the physiologically important chemicals involved in brain function have drawn much attention for the diagnosis and treatment of brain diseases and neurological disorders. This paper reports a novel method for fabrication of enzyme entrapped-conducting polymer nanofibers that offer higher sensitivity and increased lifetime compared to glucose sensors that are based on conducting polymer films.

Keywords: biosensors; conducting polymers; glucose; microelectrodes; nanofibers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus niger / enzymology
  • Biosensing Techniques / methods*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Electric Conductivity*
  • Electrochemistry
  • Electron Transport
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism
  • Glucose / analysis
  • Glucose / chemistry
  • Glucose Oxidase / chemistry
  • Glucose Oxidase / metabolism
  • Nanofibers / chemistry*
  • Polymers / chemistry*

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Enzymes, Immobilized
  • Polymers
  • poly(3,4-ethylene dioxythiophene)
  • Glucose Oxidase
  • Glucose