Drug targeting using solid lipid nanoparticles

Elham Rostami; Soheila Kashanian; Abbas H Azandaryani; Hossain Faramarzi; Jafar Ezzati Nazhad Dolatabadi; Kobra Omidfar

doi:10.1016/j.chemphyslip.2014.03.006

Drug targeting using solid lipid nanoparticles

Chem Phys Lipids. 2014 Jul:181:56-61. doi: 10.1016/j.chemphyslip.2014.03.006. Epub 2014 Apr 6.

Authors

Elham Rostami¹, Soheila Kashanian², Abbas H Azandaryani³, Hossain Faramarzi¹, Jafar Ezzati Nazhad Dolatabadi⁴, Kobra Omidfar⁵

Affiliations

¹ Larestan School of Medical Science, Larestan, Iran.
² Faculty of Chemistry, Nanoscience and Nanotechnology Research Center and Sensor and Biosensor Research Center, Razi University, P.O. Box 67149, Kermanshah, Iran. Electronic address: kashanian_s@yahoo.com.
³ Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
⁴ Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Iran.

PMID: 24717692
DOI: 10.1016/j.chemphyslip.2014.03.006

Abstract

The present review aims to show the features of solid lipid nanoparticles (SLNs) which are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Because of some unique features of SLNs such as their unique size dependent properties it offers possibility to develop new therapeutics. A common denominator of all these SLN-based platforms is to deliver drugs into specific tissues or cells in a pathological setting with minimal adverse effects on bystander cells. SLNs are capable to incorporate drugs into nanocarriers which lead to a new prototype in drug delivery which maybe used for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of targeted solid lipid nanoparticles discussing their types such as antibody SLN, magnetic SLN, pH sensitive SLN and cationic SLN.

Keywords: Antibody; Drug targeting; Magnetic SLN; Solid lipid nanoparticle; pH-sensitive.

Publication types

Review

MeSH terms

Antibodies / metabolism
Drug Carriers / chemistry*
Humans
Hydrogen-Ion Concentration
Lipids / chemistry*
Nanoparticles*
Nanotechnology / methods*

Substances

Antibodies
Drug Carriers
Lipids