Abstract
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / drug effects
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Brain / enzymology
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology
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Cholinesterases / metabolism*
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Complex Mixtures / chemistry
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology
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Crystallography, X-Ray
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Enzyme Assays
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Ethylenediamines / chemistry
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Iron / chemistry*
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Ligands
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Manganese / chemistry*
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Nickel / chemistry*
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Pyridines / chemistry
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Rats
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Schiff Bases / chemistry
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Triazines / chemistry*
Substances
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Cholinesterase Inhibitors
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Complex Mixtures
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Coordination Complexes
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Ethylenediamines
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Ligands
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Pyridines
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Schiff Bases
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Triazines
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picolinaldehyde
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tris(2-aminoethyl)amine
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Manganese
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trithiocyanuric acid
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Nickel
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Iron
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Cholinesterases