Two new cytotoxic indole alkaloids from a deep-sea sediment derived metagenomic clone

Mar Drugs. 2014 Apr 8;12(4):2156-63. doi: 10.3390/md12042156.

Abstract

Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cloning, Molecular
  • Drug Screening Assays, Antitumor
  • Escherichia coli / genetics*
  • Fermentation
  • Geologic Sediments / microbiology
  • Humans
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Metagenomics

Substances

  • Antineoplastic Agents
  • Indole Alkaloids