The Anticancer Properties and Apoptosis-inducing Mechanisms of Cinnamaldehyde and the Herbal Prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang) in Human Hepatoma Cells

Liang-Tzung Lin; Shu-Jing Wu; Chun-Ching Lin

doi:10.4103/2225-4110.119732

The Anticancer Properties and Apoptosis-inducing Mechanisms of Cinnamaldehyde and the Herbal Prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang) in Human Hepatoma Cells

J Tradit Complement Med. 2013 Oct;3(4):227-33. doi: 10.4103/2225-4110.119732.

Authors

Liang-Tzung Lin¹, Shu-Jing Wu², Chun-Ching Lin³

Affiliations

¹ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Department of Nutritional Health, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
³ School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

Hepatocellular carcinoma (HCC) has long been one of the most important causes of cancer mortality in the world. Many natural products and traditional herbal medicines have been used to treat HCC in Asian countries such as Japan, Korea, Taiwan, and China. The present review aims to describe the anticancer properties and apoptotic mechanisms of cinnamaldehyde, the bioactive ingredient isolated from cinnamon trees, and the herbal prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang; HLJDT) against human hepatoma cells in vitro and in vivo. Implication of their treatment for the development of targeted therapy against HCC is discussed.

Keywords: Anticancer; Apoptosis; Cinnamaldehyde; Hepatoma; Huang-Lian-Jie-Du-Tang.

Publication types

Review