Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Cigdem Aydin; Zafer Cetin; Ozan Salim; Orhan Kemal Yucel; Levent Undar; Sibel Berker Karauzum

doi:10.1155/2014/582016

Previously Unreported Chromosomal Aberrations of t(3;3)(q29;q23), t(4;11)(q21;q23), and t(11;18)(q10;q10) in a Patient with Accelerated Phase Ph+ CML

Case Rep Genet. 2014:2014:582016. doi: 10.1155/2014/582016. Epub 2014 Feb 23.

Authors

Cigdem Aydin¹, Zafer Cetin¹, Ozan Salim², Orhan Kemal Yucel², Levent Undar², Sibel Berker Karauzum¹

Affiliations

¹ Department of Medical Biology and Genetics, School of Medicine, Akdeniz University, 07058 Antalya, Turkey.
² Department of Hematology, School of Medicine, Akdeniz University, 07058 Antalya, Turkey.

Abstract

Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which is characterized by the presence of the classical or variant Philadelphia translocations. During the progression to blastic phase of the disease secondary chromosomal abnormalities may emerge. Such secondary chromosomal abnormalities are nonrandom, the more frequent ones being trisomy 8 and 19, supernumerary i(17q), and extra Philadelphia chromosomes. Furthermore, a minor percentage of the patients may acquire different secondary chromosomal abnormalities including translocations between other chromosomes. We report here a patient with Ph+ CML presenting secondary chromosomal abnormalities including t(4;11)(q21;q23), t(3;3)(q29;q23) and t(11;18)(q10;q10) during the course of CML progression.