Abstract
A virus-activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high-density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.
Keywords:
3D printing; bone regeneration; nanofibers; phage display; scaffolds.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacteriophages / chemistry*
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Biocompatible Materials / chemistry
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Biocompatible Materials / pharmacology*
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Bone and Bones / blood supply
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Bone and Bones / cytology
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Bone and Bones / drug effects
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Bone and Bones / physiology*
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Mesenchymal Stem Cells / drug effects
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Nanofibers*
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Neovascularization, Physiologic / drug effects*
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Oligopeptides / chemistry
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Osteogenesis / drug effects*
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Printing, Three-Dimensional*
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Tissue Scaffolds / chemistry
Substances
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Biocompatible Materials
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Oligopeptides
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arginyl-glycyl-aspartic acid