Abstract
Five new terpenes (1-5) and ten known compounds (6-15) were isolated from Inula japonica, and their structures were identified by spectroscopic analysis. Compounds 3 and 14 showed positive inhibitory effects on nitric oxide production. Furthermore, compound 14 suppressed both leukotriene C4 synthesis and degranulation in c-kit ligand-induced bone marrow-derived mast cells.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cell Degranulation / drug effects*
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Cell Line
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Disease Models, Animal
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Flowers / chemistry
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Inhibitory Concentration 50
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Inula / chemistry*
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Leukotriene C4 / analysis
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Leukotriene C4 / metabolism
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Lipopolysaccharides / metabolism
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Macrophages / drug effects
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Macrophages / metabolism
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Male
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Mast Cells / drug effects
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Mast Cells / physiology*
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Medicine, East Asian Traditional
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Mice
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Mice, Inbred BALB C
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Molecular Structure
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Nitric Oxide / analysis
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Nitric Oxide / metabolism
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal
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Terpenes / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology*
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Plant Extracts
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Terpenes
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Leukotriene C4
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Nitric Oxide