Anti-inflammatory terpenes from flowers of Inula japonica

Planta Med. 2014 May;80(7):583-9. doi: 10.1055/s-0034-1368353. Epub 2014 Apr 7.

Abstract

Five new terpenes (1-5) and ten known compounds (6-15) were isolated from Inula japonica, and their structures were identified by spectroscopic analysis. Compounds 3 and 14 showed positive inhibitory effects on nitric oxide production. Furthermore, compound 14 suppressed both leukotriene C4 synthesis and degranulation in c-kit ligand-induced bone marrow-derived mast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Degranulation / drug effects*
  • Cell Line
  • Disease Models, Animal
  • Flowers / chemistry
  • Inhibitory Concentration 50
  • Inula / chemistry*
  • Leukotriene C4 / analysis
  • Leukotriene C4 / metabolism
  • Lipopolysaccharides / metabolism
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Male
  • Mast Cells / drug effects
  • Mast Cells / physiology*
  • Medicine, East Asian Traditional
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Nitric Oxide / analysis
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Plant Extracts
  • Terpenes
  • Leukotriene C4
  • Nitric Oxide