Abstract
A new benzyl ester, reessiate (1), anthraquinone, islandicin (2), ergosterol and seven ergosterol derivatives (3-9) were isolated from the fungus Gymnoascus reessii. All structures were identified by spectroscopic methods. This is the first report of their isolation from this fungus. Compounds 4-7 and 9 exhibited antimalarial activity against Plasmodium falciparum with IC50 values in the range of 3.3-4.5 μg/mL. In addition, 4 showed cytotoxicity against KB, MCF7 and NCI-H187 cancer cell lines. It was found that 4 has cytotoxic effect to MCF7 (IC50 = 7.9 μg/mL) lower than Doxorubicin (IC50 = 8.5 μg/mL).
Keywords:
Gymnoascus reessii; antimalaria; benzyl ester; cytotoxicity; ergosterol derivative.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Ascomycota / chemistry*
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Benzyl Compounds / chemistry
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Benzyl Compounds / isolation & purification*
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification*
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Ergosterol / pharmacology
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Esters
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Female
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Humans
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Inhibitory Concentration 50
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KB Cells
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Molecular Structure
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Plasmodium falciparum / drug effects*
Substances
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Anthraquinones
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Antimalarials
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Benzyl Compounds
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Esters
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reessiate
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funiculosin (anthraquinone)
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Ergosterol