Placotylene A, an inhibitor of the receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation, from a Korean sponge Placospongia sp

Mar Drugs. 2014 Apr 3;12(4):2054-65. doi: 10.3390/md12042054.

Abstract

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Diynes / chemistry
  • Diynes / isolation & purification
  • Diynes / pharmacology*
  • Dose-Response Relationship, Drug
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Mice, Inbred ICR
  • Osteoclasts / drug effects*
  • Osteoclasts / metabolism
  • Porifera / chemistry*
  • RANK Ligand / metabolism
  • Republic of Korea
  • Stereoisomerism

Substances

  • 14-iodotetradeca-13-en-3,5-diyn-1-ol
  • Diynes
  • Fatty Alcohols
  • RANK Ligand