Sesquiterpenes from the saprotrophic fungus Granulobasidium vellereum (Ellis & Cragin) Jülich

Phytochemistry. 2014 Jun:102:197-204. doi: 10.1016/j.phytochem.2014.03.012. Epub 2014 Apr 3.

Abstract

Twelve sesquiterpenes comprising either the protoilludane or the rare cerapicane carbon skeletons were obtained from the saprotrophic wood decomposing fungus Granulobasidium vellereum; 2a-hydroxycoprinolone (1), 3-hydroxycoprinolone (2), coprinolone diol B (3), granulodiene A (4), granulodiene B (5), granulone A (6), 8-deoxy-4a-hydroxytsugicoline B (7), granulone B (8), demethylgranulone (9), cerapicolene (10), as well as the known compounds radudiol and Δ(6)-coprinolone. The structures were determined using spectroscopic methods and biosynthetic considerations. Granulone A had growth stimulating effect on the total elongation of lettuce seedlings. None of the isolated compounds showed any antifungal effect.

Keywords: Cerapicane; Granulobasidium vellereum; Growth promotor; Protoilludane; Sesquiterpenes; Structural elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Fungi / chemistry*
  • Fungi / drug effects*
  • Molecular Conformation
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Species Specificity
  • Stereoisomerism

Substances

  • Antifungal Agents
  • Sesquiterpenes