Comorbidities in patients with crystal diseases and hyperuricemia

Sebastian E Sattui; Jasvinder A Singh; Angelo L Gaffo

doi:10.1016/j.rdc.2014.01.005

Comorbidities in patients with crystal diseases and hyperuricemia

Rheum Dis Clin North Am. 2014 May;40(2):251-78. doi: 10.1016/j.rdc.2014.01.005. Epub 2014 Feb 19.

Authors

Sebastian E Sattui¹, Jasvinder A Singh², Angelo L Gaffo³

Affiliations

¹ Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama, Faculty Office Tower 813, 510 20th Street South, Birmingham, AL 35294, USA.
² Medicine Service, Center for Surgical Medical Acute Care Research and Transitions (C-SMART), 700 19th Street South, Birmingham VA Medical Center, Birmingham, AL 35233, USA; Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama, Faculty Office Tower 805B, 200 First Street South West, Rochester, MN 55905, USA; Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
³ Section of Rheumatology, Veterans Affairs Medical Center, 700 19th Street South, Birmingham, AL 35233, USA; Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama, Shelby Building 201, 1825 University Boulevard, Birmingham, AL 35294, USA. Electronic address: agaffo@uab.edu.

Abstract

Crystal arthropathies are among the most common causes of painful inflammatory arthritis. Gout, the most common example, has been associated with cardiovascular and renal disease. In recent years, evidence for these associations and those involving other comorbidities, such as the metabolic syndrome, have emerged, and the importance of asymptomatic hyperuricemia has been established. In this review, an update on evidence, both experimental and clinical, is presented, and associations between hyperuricemia, gout, and several comorbidities are described. Causality regarding calcium pyrophosphate arthropathy and associated comorbidities is also reviewed.

Keywords: Calcium pyrophosphate arthropathy; Cardiovascular disease; Comorbidities; Crystal arthropathies; Gout; Hyperuricemia; Metabolic syndrome; Renal disease.

Publication types

Review

MeSH terms

Acute Kidney Injury / epidemiology
Cardiovascular Diseases / epidemiology*
Cerebrovascular Disorders / epidemiology
Chondrocalcinosis / epidemiology*
Comorbidity
Coronary Disease / epidemiology
Diabetes Mellitus / epidemiology*
Gout / epidemiology*
Heart Failure / epidemiology
Humans
Hypertension / epidemiology
Hyperuricemia / epidemiology*
Metabolic Syndrome / epidemiology*
Neurodegenerative Diseases / epidemiology
Osteoarthritis / epidemiology
Renal Insufficiency, Chronic / epidemiology*

Supplementary concepts

Chondrocalcinosis 2

Abstract

Publication types

MeSH terms

Supplementary concepts

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