Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system

Abstract

The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.

Keywords: Anti- myelin oligodendrocyte glycoprotein antibodies; Anti-aquaporin 4 antibodies; Cell-based immunofluorescence assay; Multiple sclerosis; Neuromyelitis optica; Optic neuritis.