A new quinoline alkaloid from the roots of Dictamnus angustifolius

Chin J Nat Med. 2014 Mar;12(3):222-4. doi: 10.1016/S1875-5364(14)60037-6.

Abstract

Aim: To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).

Method: The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.

Results: A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).

Conclusion: Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.

Keywords: 5-Methoxylrobustine; Cytotoxicity; Dictamnus angustifolius; Quinoline alkaloids.

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Cell Line, Tumor
  • Dictamnus / chemistry*
  • Humans
  • Hydroxyquinolines / chemistry
  • Hydroxyquinolines / isolation & purification*
  • Hydroxyquinolines / pharmacology
  • Hydroxyquinolines / therapeutic use
  • Molecular Structure
  • Phytotherapy*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry*
  • Quinolines / chemistry
  • Quinolines / isolation & purification
  • Quinolines / pharmacology
  • Quinolines / therapeutic use

Substances

  • 5-methoxylrobustine
  • Antineoplastic Agents, Phytogenic
  • Hydroxyquinolines
  • Plant Extracts
  • Quinolines
  • skimmianine
  • dictamnine