A one-step microwave-assisted synthetic method for an O/S-chemoselective route to derivatives of the first adenosine A3 PET radiotracer

Molecules. 2014 Apr 2;19(4):4076-82. doi: 10.3390/molecules19044076.

Abstract

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2-8 in a single step.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorine Radioisotopes / chemistry*
  • Humans
  • Microwaves
  • Nicotinic Acids / chemical synthesis*
  • Positron-Emission Tomography
  • Receptor, Adenosine A3 / analysis*
  • Reference Standards
  • Structure-Activity Relationship

Substances

  • 5-(2-fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate
  • Fluorine Radioisotopes
  • Nicotinic Acids
  • Receptor, Adenosine A3