Abstract
The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2-8 in a single step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Fluorine Radioisotopes / chemistry*
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Humans
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Microwaves
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Nicotinic Acids / chemical synthesis*
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Positron-Emission Tomography
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Receptor, Adenosine A3 / analysis*
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Reference Standards
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Structure-Activity Relationship
Substances
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5-(2-fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate
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Fluorine Radioisotopes
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Nicotinic Acids
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Receptor, Adenosine A3