Abstract
Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1-3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vitro assayed for cytotoxic activity against human hepatocarcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Adenocarcinoma / drug therapy
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Animals
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Anthozoa / metabolism*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy
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Carcinoma, Hepatocellular / drug therapy
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Egypt
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Hep G2 Cells
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Humans
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Liver Neoplasms / drug therapy
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MCF-7 Cells
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Magnetic Resonance Spectroscopy
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Terpenes / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology*
Substances
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Antineoplastic Agents
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Terpenes
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sarcophine
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4-Butyrolactone