Abstract
A new triterpene, malaytaraxerate (1), and four known compounds, taraxerol (2), taraxerone (3), docosyl isoferulate (4) and docosanoic acid 2',3'-dihydroxypropyl ester (5), were isolated from the acetone extract of Sapium baccatum stem bark. The structures of the isolated compounds were determined using several spectroscopic methods, including UV-Vis, FT-IR, 1D and 2D NMR, and mass spectrometry. Major isolated compounds were assayed for cytotoxicity. The chemotaxonomic significance of this plant was also studied.
Keywords:
Euphorbiaceae; Sapium baccatum; cytotoxicity; malaytaraxerate; triterpenoid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Algorithms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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HT29 Cells
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Humans
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Mice
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Molecular Structure
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Oleanolic Acid / analogs & derivatives
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Sapium / chemistry*
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Spectroscopy, Fourier Transform Infrared
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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malaytaraxerate
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Oleanolic Acid
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taraxerol
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taraxerone