Progesterone receptor expression in sinonasal leiomyoma: a case report and review of the literature

Int J Clin Exp Pathol. 2014 Feb 15;7(3):1224-8. eCollection 2014.

Abstract

Leiomyomas are benign myogenic tumors that seldom occur in the sinonasal cavity. They were commonly found in middle-aged adults with a female predominance. Clinical symptoms include nasal obstruction with discharge, nasal bleeding and pain. We describe the case of a 48 year-old woman with a leiomyoma arising from right inferior nasal turbinate. Transnasal endoscopic excision was performed with satisfied result. The tumor was found to be progesterone receptor positive on immunohistochemical analysis. The clinical findings are addressed with a review of the literature. To the best of our knowledge, this is the third reported case that supports the growth of the tumor may be hormone-dependent.

Keywords: Paranasal sinuses; angioleiomyoma; intranasal surgery; nasal cavity; progesterone receptor; sex hormone-binding globulin receptor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Female
  • Humans
  • Immunohistochemistry
  • Leiomyoma / metabolism*
  • Leiomyoma / pathology*
  • Middle Aged
  • Nose Neoplasms / metabolism*
  • Nose Neoplasms / pathology*
  • Paranasal Sinus Neoplasms / metabolism
  • Paranasal Sinus Neoplasms / pathology
  • Receptors, Progesterone / biosynthesis*

Substances

  • Biomarkers, Tumor
  • Receptors, Progesterone