Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma

Int J Clin Exp Pathol. 2014 Feb 15;7(3):914-22. eCollection 2014.

Abstract

Special AT rich sequence binding protein 1 (SATB1) play an important role in many cancers, but the role of SATB1 in nasopharyngeal carcinoma (NPC) is still not full understand. Immunofluorescence staining showed that SATB1 was mainly localized in the nuclei in CNE-2 cell. After successful down-regulation of SABT1 in NPC cell line CNE-2 by shRNA, compared to parental CNE-2 and control shRNA group, the capacity of the proliferation, migration, invasion and drug resistance of CNE-2 cell was reduced, which indicated that SATB1 may be involved in NPC development and progression. SATB1 may be a promising therapeutic target for nasopharyngeal carcinoma.

Keywords: Nasopharyngeal carcinoma; SATB1; drug resistance; invasion; proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Carcinoma
  • Cell Line, Tumor
  • Cell Movement*
  • Drug Resistance, Neoplasm / genetics*
  • Fluorescent Antibody Technique
  • Gene Silencing
  • Humans
  • Matrix Attachment Region Binding Proteins / biosynthesis
  • Matrix Attachment Region Binding Proteins / genetics*
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Neoplasms / genetics*
  • Nasopharyngeal Neoplasms / metabolism
  • Nasopharyngeal Neoplasms / pathology
  • Neoplasm Invasiveness / genetics
  • Neoplasm Invasiveness / pathology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transfection

Substances

  • Matrix Attachment Region Binding Proteins
  • SATB1 protein, human