In this paper, we consider the interaction of an electromagnetic field with two eccentric spheres. We propose a quasi-static approach in order to calculate the scattered field and the polarizability and the effective permittivity of the eccentric spheres. We analyze the behavior of the scattering parameters as a function of the dimension and position of the spherical inclusions. Moreover, we consider the case of plasmonic spheres and study the behavior of the plasmon resonances for different reciprocal positions of the two spheres.