PET and PET/CT with 68gallium-labeled somatostatin analogues in Non GEP-NETs Tumors

ScientificWorldJournal. 2014 Feb 13:2014:194123. doi: 10.1155/2014/194123. eCollection 2014.

Abstract

Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine cells. A major interest for SST receptors (SSTR) as target for in vivo diagnostic and therapeutic purposes was born since a series of stable synthetic SST-analouges PET became available, being the native somatostatin non feasible for clinical use due to the very low metabolic stability. The rationale for the employment of SST-analogues to image cancer is both based on the expression of SSTR by tumor and on the high affinity of these compounds for SSTR. The primary indication of SST-analogues imaging is for neuroendocrine tumors (NETs), which usually express a high density of SSTR, so they can be effectively targeted and visualized with radiolabeled SST-analogues in vivo. Particularly, SST-analogues imaging has been widely employed in gastroenteropancreatic (GEP) NETs. Nevertheless, a variety of tumors other than NETs expresses SSTR thus SST-analogues imaging can also be used in these tumors, particularly if treatment with radiolabeled therapeutic SST-analouges PET is being considered. The aim of this paper is to provide a concise overview of the role of positron emission tomography/computed tomography (PET/CT) with (68)Ga-radiolabeled SST-analouges PET in tumors other than GEP-NETs.

MeSH terms

  • Carcinoid Tumor / diagnosis*
  • Carcinoid Tumor / metabolism
  • Carcinoid Tumor / secondary*
  • Gallium Radioisotopes / pharmacokinetics
  • Humans
  • Multimodal Imaging / methods
  • Octreotide* / pharmacokinetics
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacokinetics
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*

Substances

  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • Octreotide