Carbon-dot-based two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA

Adv Healthc Mater. 2014 Aug;3(8):1203-1209. doi: 10.1002/adhm.201300611. Epub 2014 Apr 2.

Abstract

A simple and versatile nanoparticulate siRNA and DNA delivery vehicle is reported, based on photonic Cdots by using Alkyl-PEI2k for surface passivation.

Keywords: RNA interference; carbon dots; gene delivery; plasmid DNA; polyethylenimine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • DNA / chemistry*
  • DNA / metabolism
  • DNA / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanotubes, Carbon / chemistry
  • Photons
  • Polyethyleneimine / chemistry
  • Quantum Dots / chemistry*
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / metabolism
  • RNA, Small Interfering / pharmacology
  • Transfection
  • Transplantation, Homologous

Substances

  • Nanotubes, Carbon
  • RNA, Small Interfering
  • Polyethyleneimine
  • DNA