Abstract
Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.
Keywords:
biomaterials; nanoparticles; osteoarthritis; protein delivery.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacokinetics
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Cell Line
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Drug Carriers / administration & dosage
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Drug Carriers / chemistry*
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Drug Carriers / pharmacokinetics
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Fibronectins / administration & dosage
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Fibronectins / chemistry
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Fibronectins / pharmacokinetics
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Humans
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Injections, Intra-Articular
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Male
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Mice
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Nanoparticles / administration & dosage*
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Nanoparticles / chemistry*
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Particle Size
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Polyhydroxyethyl Methacrylate / administration & dosage
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Polyhydroxyethyl Methacrylate / chemistry
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Proteins / administration & dosage*
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Proteins / chemistry
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Proteins / pharmacokinetics
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Rats
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Rats, Inbred Lew
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Serum Albumin, Bovine / administration & dosage
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Serum Albumin, Bovine / chemistry
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Serum Albumin, Bovine / pharmacokinetics
Substances
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Anti-Inflammatory Agents
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Drug Carriers
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Fibronectins
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Proteins
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Polyhydroxyethyl Methacrylate
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Serum Albumin, Bovine