Nanoengineered particles for enhanced intra-articular retention and delivery of proteins

Adv Healthc Mater. 2014 Oct;3(10):1562-7, 1525. doi: 10.1002/adhm.201400051. Epub 2014 Mar 31.

Abstract

Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.

Keywords: biomaterials; nanoparticles; osteoarthritis; protein delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacokinetics
  • Cell Line
  • Drug Carriers / administration & dosage
  • Drug Carriers / chemistry*
  • Drug Carriers / pharmacokinetics
  • Fibronectins / administration & dosage
  • Fibronectins / chemistry
  • Fibronectins / pharmacokinetics
  • Humans
  • Injections, Intra-Articular
  • Male
  • Mice
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry*
  • Particle Size
  • Polyhydroxyethyl Methacrylate / administration & dosage
  • Polyhydroxyethyl Methacrylate / chemistry
  • Proteins / administration & dosage*
  • Proteins / chemistry
  • Proteins / pharmacokinetics
  • Rats
  • Rats, Inbred Lew
  • Serum Albumin, Bovine / administration & dosage
  • Serum Albumin, Bovine / chemistry
  • Serum Albumin, Bovine / pharmacokinetics

Substances

  • Anti-Inflammatory Agents
  • Drug Carriers
  • Fibronectins
  • Proteins
  • Polyhydroxyethyl Methacrylate
  • Serum Albumin, Bovine