Abstract
Seven new xanthone glycosides (1-7) were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds (8-13). Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were evaluated for their α-glucosidase inhibitory activities in vitro, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase. Meanwhile the effects of different substitutions on the α-glucosidase inhibitory activity of xanthone glycosides from S. bimaculata are also discussed.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Swertia / chemistry*
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Xanthones / chemistry
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Xanthones / isolation & purification
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Xanthones / pharmacology*
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alpha-Glucosidases / metabolism*
Substances
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1-O-(beta-D-xylopyranosyl-(1-4)-beta-D-glucopyranosyl)-3,8-dihydroxy-4,5-dimethoxyxanthone
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1-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranosyl)-8-hydroxy-3,4,5-trimethoxyxanthone
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8-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranosyl)-1-hydroxy-3,4,5-trimethoxyxanthone
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Enzyme Inhibitors
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Glycosides
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Plant Extracts
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Xanthones
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alpha-Glucosidases