A new approach towards the synthesis of pseudaminic acid analogues

Org Biomol Chem. 2014 May 14;12(18):2918-25. doi: 10.1039/c3ob42491j.

Abstract

The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are essential components of bacterial polysaccharides and glycoproteins. This paper describes our approach towards the synthesis of analogues of pseudaminic acid, and involves the efficient introduction of the requisite nitrogen functionalities from a readily available precursor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azides / chemistry
  • Chemistry, Organic / methods*
  • N-Acetylneuraminic Acid / chemistry
  • Sugar Acids / chemical synthesis*
  • Sugar Acids / chemistry

Substances

  • 5,7-diacetamido-3,5,7,9-tetradeoxynonulosonic acid
  • Azides
  • Sugar Acids
  • N-Acetylneuraminic Acid