Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses

Protein Sci. 2014 May;23(5):526-38. doi: 10.1002/pro.2441. Epub 2014 Mar 4.

Abstract

Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

Keywords: agonist; antagonist; cytokine; inflammation; interleukin; receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Humans
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Intercellular Signaling Peptides and Proteins / chemistry
  • Intercellular Signaling Peptides and Proteins / immunology
  • Interleukin 1 Receptor Antagonist Protein / chemistry
  • Interleukin 1 Receptor Antagonist Protein / immunology
  • Interleukin-1 / antagonists & inhibitors
  • Interleukin-1 / chemistry*
  • Interleukin-1 / immunology*
  • Interleukin-18 / chemistry
  • Interleukin-18 / immunology
  • Models, Molecular
  • Protein Conformation
  • Signal Transduction

Substances

  • Intercellular Signaling Peptides and Proteins
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Interleukin-18
  • interleukin-18 binding protein

Associated data

  • PDB/1I1B
  • PDB/1ILR
  • PDB/1IRA
  • PDB/1ITB
  • PDB/1J0S
  • PDB/2KKI
  • PDB/2KLL
  • PDB/3F62
  • PDB/3O4O
  • PDB/4DEP
  • PDB/4EKX
  • PDB/4KC3