Abstract
Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
Keywords:
agonist; antagonist; cytokine; inflammation; interleukin; receptors.
© 2014 The Protein Society.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Crystallography, X-Ray
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Humans
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Inflammation / drug therapy
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Inflammation / immunology
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Intercellular Signaling Peptides and Proteins / chemistry
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Intercellular Signaling Peptides and Proteins / immunology
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Interleukin 1 Receptor Antagonist Protein / chemistry
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Interleukin 1 Receptor Antagonist Protein / immunology
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Interleukin-1 / antagonists & inhibitors
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Interleukin-1 / chemistry*
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Interleukin-1 / immunology*
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Interleukin-18 / chemistry
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Interleukin-18 / immunology
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Models, Molecular
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Protein Conformation
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Signal Transduction
Substances
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Intercellular Signaling Peptides and Proteins
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Interleukin-18
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interleukin-18 binding protein
Associated data
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PDB/1I1B
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PDB/1ILR
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PDB/1IRA
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PDB/1ITB
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PDB/1J0S
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PDB/2KKI
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PDB/2KLL
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PDB/3F62
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PDB/3O4O
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PDB/4DEP
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PDB/4EKX
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PDB/4KC3