Abstract
In order to elucidate the involvement of melanin-concentrating hormone (MCH) and orexin-A (ORX-A) neurons of the perifornical/lateral hypothalamic areas (PF/LH) in the regulation of food intake induced by acutely reduced glucose availability, we examined the food intake response and c-Fos expression in the MCH and ORX-A neurons in the PF/LH during 2-deoxy-D-glucose (2DG)-induced glucoprivation (400 mg/kg; i.v.) and systemic insulin-induced hypoglycemia (5 U/kg; s.c.) in male Wistar rats. The administration of both 2DG and insulin stimulated food intake and induced c-Fos expression in the ORX-A neurons corresponding to food intake, but not in the MCH neurons. These data indicate that ORX-A neurons, but not MCH neurons, play a role in the short-term regulation of food intake, and that the input signals for the neurons containing MCH and ORX-A are different, and these neurons play different roles in the regulation of feeding behavior.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Glucose / metabolism
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Body Temperature Regulation
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Deoxyglucose / administration & dosage
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Disease Models, Animal
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Eating* / drug effects
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Energy Metabolism
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Feeding Behavior* / drug effects
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Hyperglycemia / chemically induced
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Hyperglycemia / metabolism*
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Hyperglycemia / psychology
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Hypothalamic Hormones / metabolism*
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Hypothalamus / drug effects
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Hypothalamus / metabolism*
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Insulin
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Intracellular Signaling Peptides and Proteins / metabolism*
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Male
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Melanins / metabolism*
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Neurons / drug effects
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Neurons / metabolism*
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Neuropeptides / metabolism*
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Orexins
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Pituitary Hormones / metabolism*
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Proto-Oncogene Proteins c-fos / metabolism
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Rats, Wistar
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Time Factors
Substances
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Blood Glucose
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Hypothalamic Hormones
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Insulin
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Intracellular Signaling Peptides and Proteins
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Melanins
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Neuropeptides
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Orexins
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Pituitary Hormones
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Proto-Oncogene Proteins c-fos
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melanin-concentrating hormone
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Deoxyglucose