Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for β-cell dysfunction and diabetes

Katarzyna Bergmann; Grazyna Sypniewska

doi:10.1016/j.clinbiochem.2014.03.007

Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for β-cell dysfunction and diabetes

Clin Biochem. 2014 May;47(7-8):529-32. doi: 10.1016/j.clinbiochem.2014.03.007. Epub 2014 Mar 24.

Authors

Katarzyna Bergmann¹, Grazyna Sypniewska²

Affiliations

¹ Department of Laboratory Medicine, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Poland. Electronic address: bergmann@vp.pl.
² Department of Laboratory Medicine, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Poland.

PMID: 24675103
DOI: 10.1016/j.clinbiochem.2014.03.007

Abstract

The discovery of new risk factors for diabetes is a major challenge for contemporary science. Pathogenesis of type 2 diabetes mellitus (T2DM) is closely related to adipose tissue dysfunction. The aim of this review was to describe recently discovered cytokines: fractalkine (CX3CL1, FKN) and secreted frizzled-related protein 4 (SFRP4) as potential biomarkers of early β cell dysfunction and diabetes. The association of CX3CL1 and SFRP4 with low-grade inflammation in adipose tissue links obesity with disturbances in insulin secretion and impaired glucose metabolism, therefore it indicates new therapeutic and preventive targets in both healthy and diabetic subjects.

Keywords: Adipocytokines; Diabetes; Fractalkine; Insulin resistance; Secreted frizzled-related protein 4.

Publication types

Review

MeSH terms

Biomarkers / metabolism*
Chemokine CX3CL1 / metabolism*
Humans
Insulin Resistance
Insulin-Secreting Cells / metabolism*
Obesity / metabolism*
Proto-Oncogene Proteins / metabolism*

Substances

Biomarkers
Chemokine CX3CL1
Proto-Oncogene Proteins
SFRP4 protein, human