Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

Wen Ai; Xiu-Ping Lin; Zhengchao Tu; Xin-Peng Tian; Xin Lu; Fredimoses Mangaladoss; Zhi-Long Zhong; Yonghong Liu

doi:10.1080/14786419.2014.891204

Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

Nat Prod Res. 2014;28(16):1219-24. doi: 10.1080/14786419.2014.891204. Epub 2014 Mar 25.

Authors

Wen Ai¹, Xiu-Ping Lin, Zhengchao Tu, Xin-Peng Tian, Xin Lu, Fredimoses Mangaladoss, Zhi-Long Zhong, Yonghong Liu

Affiliation

¹ a Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.

PMID: 24666327
DOI: 10.1080/14786419.2014.891204

Abstract

Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 μM.

Keywords: COX-2; Streptomyces axinellae; inhibitor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catechols / chemistry
Catechols / isolation & purification*
Catechols / pharmacology*
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / isolation & purification*
Cyclooxygenase 2 Inhibitors / pharmacology*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Streptomyces / chemistry*

Substances

Catechols
Cyclooxygenase 2 Inhibitors
axinelline A
Cyclooxygenase 2
PTGS2 protein, human