Abstract
A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
Keywords:
antioxidant (DPPH radical scavenging); barbituric acid; chymotrypsin; lipoxygenase; thiobarbituric acid; thiosemicarbazone; α-Glucosidase and anti-urease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Barbiturates / chemical synthesis*
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Barbiturates / chemistry
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Biphenyl Compounds / antagonists & inhibitors
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Chymotrypsin / antagonists & inhibitors
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Chymotrypsin / chemistry
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Enzyme Assays
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Lipoxygenase / chemistry
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Picrates / antagonists & inhibitors
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Thiobarbiturates / chemical synthesis*
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Thiobarbiturates / chemistry
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Urease / antagonists & inhibitors
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Urease / chemistry
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alpha-Glucosidases / chemistry
Substances
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Antioxidants
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Barbiturates
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Biphenyl Compounds
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Enzyme Inhibitors
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Picrates
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Thiobarbiturates
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1,1-diphenyl-2-picrylhydrazyl
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Lipoxygenase
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alpha-Glucosidases
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Chymotrypsin
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Urease