First experiences in application of RFLP analysis for carrier detection in preparation of prenatal diagnosis of hemophilia A in the GDR

F H Herrmann; T Kruse; M Wehnert; G Vogel; K Wulff

First experiences in application of RFLP analysis for carrier detection in preparation of prenatal diagnosis of hemophilia A in the GDR

Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):489-93.

Authors

F H Herrmann¹, T Kruse, M Wehnert, G Vogel, K Wulff

Affiliation

¹ Institute of Medical Genetics, Ernst-Moritz-Arndt-University, Greifswald, GDR.

PMID: 2465959

Abstract

The application of the intragenic probe F8 e16-19 of factor VIII gene is reported for carrier detection in preparation of prenatal diagnosis of hemophilia A in a family at risk. The proband's mother is heterozygous for the Bcl I polymorphism and prenatal diagnosis can be offered to this family.

MeSH terms

DNA Probes
Female
Genetic Carrier Screening / methods*
Germany, East
Hemophilia A / diagnosis*
Hemophilia A / genetics
Humans
Male
Pedigree
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*
Prenatal Diagnosis / methods*

Substances

DNA Probes