Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment

J Biophotonics. 2015 May;8(5):382-91. doi: 10.1002/jbio.201400007. Epub 2014 Mar 21.

Abstract

Potential antimicrobial effects of sequential applications of tissue-tolerable plasma (TTP) and the conventional liquid antiseptic octenidine dihydrochloride (ODC) were investigated. 34 patients with chronic leg ulcers were treated with TTP, ODC or a combination of both. The bacterial colonization was measured semi-quantitatively before and immediately after treatment and changes in the microbial strains' compositions before and after antiseptic treatments were analyzed. All antiseptic procedures reduced the bacterial counts significantly. The sequential application of TTP and ODC displayed the highest antimicrobial efficacy. Me combined use of TTP and conventional antiseptics might represent the most efficient strategy for antiseptic treatment of chronic wounds.

Keywords: antiseptic efficacy; chronic wounds; octenidine dihydrochloride (ODC); tissue tolerable plasma (TTP); wound disinfection.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Infective Agents, Local / pharmacology*
  • Anti-Infective Agents, Local / therapeutic use
  • Drug Interactions
  • Exudates and Transudates / drug effects
  • Female
  • Humans
  • Leg Ulcer / drug therapy
  • Leg Ulcer / microbiology
  • Leg Ulcer / pathology
  • Leg Ulcer / physiopathology
  • Male
  • Middle Aged
  • Pain / chemically induced
  • Plasma Gases / adverse effects
  • Plasma Gases / pharmacology*
  • Plasma Gases / therapeutic use
  • Wound Healing / drug effects*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Plasma Gases