Options for biomedical analysis continue to evolve from many fields of study, employing diverse detection and quantification methods. New technologies in this arena focus on improving the sensitivity of analysis and the speed of testing, as well as producing systems at low cost which can be used on site as a point-of-care device for telemedicine applications. In this article, the most important original experimental platforms as well as current commercial approaches to biomedical analysis are critically chosen and reviewed, covering January 2010 to January 2014. While literature is quite broad and numerous, there is clear emphasis on biological recognition and imaging for the most impactful works. The analytical approaches are discussed in terms of their utility in diagnostics and biomedical testing.