Minimal residual disease in breast cancer: in blood veritas

Clin Cancer Res. 2014 May 15;20(10):2505-7. doi: 10.1158/1078-0432.CCR-14-0370. Epub 2014 Mar 21.

Abstract

A blood-based molecular test might direct recommendations for systemic therapies in patients with early-stage breast cancer undergoing surgery with curative intent. A new study suggests that droplet digital PCR (ddPCR) can be used to detect cancer-specific DNA alterations in plasma with sensitivity suitable for monitoring minimal residual disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / genetics*
  • DNA, Neoplasm / blood*
  • DNA, Neoplasm / genetics*
  • Female
  • Humans

Substances

  • DNA, Neoplasm