A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release

Soft Matter. 2014 May 21;10(19):3441-50. doi: 10.1039/c3sm53157k. Epub 2014 Mar 20.

Abstract

This paper studied the synthesis, characterization and use of the magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which was crosslinked with epichlorohydrin for subsequent incorporation of iron oxide magnetic nanoparticles. The characterization revealed that the magnetic material comprises about 10% of the hydrogel. This material is comprised of magnetite and maghemite and exhibits ferro-ferrimagnetic behavior. The average particle size is 4.2 nm. There was high incorporation efficiency of maleimides in the magnetic nanogel. The release was of sustained character and there was a greater release when an external magnetic field was applied. The mathematical model that best explained the process of drug release by the magnetic hydrogel was that of Peppas-Sahlin. The magnetic nanogel proved to be an excellent candidate for use in drug-delivery systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Calorimetry, Differential Scanning
  • Cattle
  • Chitosan / analogs & derivatives*
  • Chitosan / chemical synthesis
  • Chitosan / chemistry
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Liberation
  • Epichlorohydrin / chemistry
  • Magnetics
  • Magnetite Nanoparticles / chemistry
  • Nanogels
  • Particle Size
  • Polyethylene Glycols / chemistry*
  • Polyethyleneimine / chemistry*
  • Serum Albumin, Bovine / chemistry
  • Spectroscopy, Mossbauer
  • Thermogravimetry

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Magnetite Nanoparticles
  • Nanogels
  • O-carboxymethylchitosan
  • polyethylene glycol polyethyleneimine nanogel
  • Epichlorohydrin
  • Serum Albumin, Bovine
  • Polyethylene Glycols
  • Polyethyleneimine
  • Chitosan