Our current environment has led to a vicious cycle of physical inactivity, obesity, and chronic inflammation, creating the "perfect storm" for metabolic diseases. White adipose tissue (WAT) is the major source of obesity/ inactivity-related inflammation; in turn, inflammation leads to insulin resistance and metabolic dysfunction. Inactivity, even in the absence of weight gain, disrupts WAT metabolism, while exercise mitigates WAT inflammation. The antiinflammatory mechanism(s) of exercise require additional study. Two current hypotheses include: (1) exercise-mediated antiinflammatory cytokine secretion, and (2) exercise-mediated improvements in adipocyte oxidative capacity.