Fusion of PET and MRI for staging of uterine cervical cancer: comparison with contrast-enhanced (18)F-FDG PET/CT and pelvic MRI

Clin Imaging. 2014 Jul-Aug;38(4):464-469. doi: 10.1016/j.clinimag.2014.02.006. Epub 2014 Feb 15.

Abstract

Purpose: To investigate the fusion of pelvic magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (PET) for assessment of locoregional extension and nodal staging of cervical cancer.

Methods: PET/computed tomography (CT), MRI, and non-fused and fusion of PET and MRI for assessing the extent of the primary tumor and metastasis to nodes were evaluated.

Results: Accuracy for T-status was 83.3% for fused and non-fused PET/MRI and MRI proved significantly more accurate than PET/CT (53.3%) (P=.0077). Sensitivity, specificity, and accuracy for nodal metastasis were 92.3%, 88.2%, and 90.0% for fused PET/MRI and PET/contrast-enhanced CT; 84.6%, 94.1%, and 90.0% for non-fused PET/MRI; and 69.2%, 100%, and 86.7% for MRI.

Conclusion: Fused PET/MRI combines the individual advantages of MRI and PET.

Keywords: Fused imaging; MRI; PET/CT; Staging; Uterine cervical cancer.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Magnetic Resonance Imaging*
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Pelvis / diagnostic imaging*
  • Pelvis / pathology
  • Positron-Emission Tomography*
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed*
  • Uterine Cervical Neoplasms / diagnostic imaging*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Contrast Media
  • Fluorodeoxyglucose F18