The 166th annual meeting of the American Psychiatric Association was held in May 2013. where the long-awaited DSM-5 was released with a number of seminars and symposia organized. This review primarily focused on changes in DSM-5 from its predecessor, DSM-IV-TR. Examples of such changes include the removal of subtypes from schizophrenia, an increase in clinical presentations that are described by specifiers for bipolar disorders, the removal of exclusion criteria of bereavement from depressive disorders, and reconceptualization of pervasive developmental disorders. These changes seemed to collectively point to a transition from categorical to dimensional conceptualization of mental disorders, an increase in the use of specifiers, and increased reliance on clinical judgment Criticism of DSM-5 was also introduced, followed by discussion on how diagnostic classification systems are expected to evolve.