Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages

Henrik Boije; Ryan B MacDonald; William A Harris

doi:10.1016/j.conb.2014.02.014

Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages

Curr Opin Neurobiol. 2014 Aug;27(100):68-74. doi: 10.1016/j.conb.2014.02.014. Epub 2014 Mar 15.

Authors

Henrik Boije¹, Ryan B MacDonald¹, William A Harris²

Affiliations

¹ Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK.
² Department of Physiology, Development and Neuroscience, Cambridge University, Cambridge, UK. Electronic address: wah20@cam.ac.uk.

Abstract

Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field when we may never fully explain the behavior of individual progenitor cells?

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / physiology*
Cell Lineage / physiology*
Humans
Models, Neurological*
Retina / cytology*
Stochastic Processes*

Abstract

Publication types

MeSH terms

Grants and funding