Charcoal hemoperfusion in bupropion overdose

Hızır Ufuk Akdemir; Fatih Calışkan; Latif Duran; Celal Katı; Bülent Güngörer; Metin Ocak

doi:10.1016/j.jfma.2014.01.019

Charcoal hemoperfusion in bupropion overdose

J Formos Med Assoc. 2014 Oct;113(10):754-5. doi: 10.1016/j.jfma.2014.01.019. Epub 2014 Mar 11.

Authors

Hızır Ufuk Akdemir¹, Fatih Calışkan², Latif Duran², Celal Katı², Bülent Güngörer², Metin Ocak²

Affiliations

¹ Department of Emergency Medicine, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey. Electronic address: hufukakdemir@hotmail.com.
² Department of Emergency Medicine, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.

PMID: 24636552
DOI: 10.1016/j.jfma.2014.01.019

Abstract

Bupropion is a relatively new and popular medication for depression, with seizures as its major side effect. In the literature, there are insufficient data about hemodialysis following bupropion overdose. A 23-year-old female patient was brought to our emergency department with acute change in mental status and seizure after deliberate self-poisoning with approximately 25-30 tablets of bupropion hydrochloride. Her Glasgow coma scale score was 8/15. The patient underwent hemodialysis about 4 hours later. After 4 hours of extracorporeal treatment, she became conscious and was extubated. We present a case of full recovery after charcoal hemoperfusion following a bupropion overdose.

Keywords: bupropion; hemoperfusion; overdose; seizure.

Publication types

Case Reports

MeSH terms

Antidepressive Agents, Second-Generation / poisoning*
Antidotes / therapeutic use*
Bupropion / poisoning*
Charcoal / therapeutic use*
Depressive Disorder / drug therapy
Drug Overdose / therapy*
Female
Hemoperfusion / methods*
Humans
Young Adult

Substances

Antidepressive Agents, Second-Generation
Antidotes
Bupropion
Charcoal