Metabolites from the endophytic fungus HP-1 of Chinese eaglewood

Chin J Nat Med. 2014 Feb;12(2):151-3. doi: 10.1016/S1875-5364(14)60025-X.

Abstract

Aim: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood.

Methods: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis.

Results: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol (1), 4-hydroxyphenylacetic acid (2), 4-hydroxyphenethyl alcohol (3), and 5-hydroxymethyl-2-furancarboxaldehyde (4).

Conclusion: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.

Keywords: Antibacterial activity; Chaetomium sp.; Chinese eaglewood; Endophytic fungus; Metabolites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Endophytes / chemistry*
  • Fungi / chemistry*
  • Phenylacetates / chemistry
  • Phenylacetates / isolation & purification
  • Phenylacetates / pharmacology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Thymelaeaceae / microbiology*
  • Wood / microbiology

Substances

  • Anti-Bacterial Agents
  • Phenylacetates
  • Sesquiterpenes
  • 4-hydroxyphenylacetic acid