Aim: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood.
Methods: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis.
Results: Four compounds were isolated and identified as 3α, 3β, 10β-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol (1), 4-hydroxyphenylacetic acid (2), 4-hydroxyphenethyl alcohol (3), and 5-hydroxymethyl-2-furancarboxaldehyde (4).
Conclusion: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.
Keywords: Antibacterial activity; Chaetomium sp.; Chinese eaglewood; Endophytic fungus; Metabolites.
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