Integrating oxaliplatin with highly luminescent carbon dots: an unprecedented theranostic agent for personalized medicine

Adv Mater. 2014 Jun 4;26(21):3554-60. doi: 10.1002/adma.201306192. Epub 2014 Mar 14.

Abstract

A theranostic nanomedicine (CD-Oxa) is synthesized by means of the condensation reaction between the amino groups on the surface of fluorescent carbon dots (CDs) and the carboxyl group of the oxaliplatin derivative Oxa(IV)-COOH. CD-Oxa, which integrates the optical properties of CDs and the anticancer function of oxaliplatin, could be used for simultaneous drug delivery and fluorescent tracking.

Keywords: bioimaging; bionanotechnology; carbon nanoparticles; oxaliplatin; personalized medicine; theranostics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Carbon Compounds, Inorganic / chemical synthesis
  • Carbon Compounds, Inorganic / chemistry*
  • Carbon Compounds, Inorganic / therapeutic use
  • Cell Line
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Monitoring / methods
  • Fibroblasts / drug effects
  • Fluorescence*
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Mice
  • Nanomedicine / methods
  • Optical Imaging / methods
  • Organoplatinum Compounds / chemical synthesis
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / therapeutic use
  • Oxaliplatin
  • Particle Size
  • Precision Medicine / methods
  • Quantum Dots / chemistry*
  • Quantum Dots / therapeutic use

Substances

  • Antineoplastic Agents
  • Carbon Compounds, Inorganic
  • Organoplatinum Compounds
  • Oxaliplatin