1 Department of Pediatrics, Pediatric and Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS San Matteo, Pavia, Italy Epidemiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy Department of Internal Medicine and, Therapeutics, University of Pavia, Fondazione IRCCS San Matteo, Pavia, Italy Department of Pediatrics, Pediatric and Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.