Proliferating cell unclear antigen-associated factor (PAF15): a novel oncogene

Chanlu Xie; Mu Yao; Qihan Dong

doi:10.1016/j.biocel.2014.02.024

Proliferating cell unclear antigen-associated factor (PAF15): a novel oncogene

Int J Biochem Cell Biol. 2014 May:50:127-31. doi: 10.1016/j.biocel.2014.02.024. Epub 2014 Mar 12.

Authors

Chanlu Xie¹, Mu Yao², Qihan Dong³

Affiliations

¹ School of Science and Health, The University of Western Sydney, Australia.
² Central Clinical School and Bosch Institute, The University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
³ School of Science and Health, The University of Western Sydney, Australia; Central Clinical School and Bosch Institute, The University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: q.dong@uws.edu.au.

PMID: 24631643
DOI: 10.1016/j.biocel.2014.02.024

Abstract

Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24). Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival. Ectopic expression of PAF15 in mouse fibroblasts increases colony formation and tumourigenicity. PAF15 is aberrantly increased in various human malignancies with poor prognosis. Collectively, PAF15 may contribute to carcinogenesis and represents one of the potential therapeutic targets in the treatment of cancer.

Keywords: Cancer; DNA replication and DNA repair; KIAA0101; PAF15; PCNA associated factor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Damage
DNA Repair
DNA Replication
Humans
Oncogenes
Proliferating Cell Nuclear Antigen / genetics*

Substances

Proliferating Cell Nuclear Antigen