Abstract
Dihydropyridines (+)-PN200-110 and (+/-)-Bay-K-8644 inhibit or potentiate, respectively, catecholamine release evoked by DMPP- or K-stimulation of perfused cat adrenal glands. Since both, secretion of adrenaline and noradrenaline are equally affected, and these two drugs specifically act on voltage-dependent chromaffin Ca channels, it seems that secretion of each amine from their respective cell is regulated by the same type of channel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
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Adrenal Medulla / drug effects
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Adrenal Medulla / metabolism*
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Animals
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Calcium / physiology*
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Calcium Channel Blockers / pharmacology*
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Cats
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Dihydropyridines / pharmacology*
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Dimethylphenylpiperazinium Iodide / pharmacology
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Epinephrine / metabolism*
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In Vitro Techniques
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Ion Channels / drug effects
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Ion Channels / physiology*
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Isradipine
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Norepinephrine / metabolism*
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Oxadiazoles / pharmacology
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Potassium / pharmacology
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Reference Values
Substances
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Calcium Channel Blockers
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Dihydropyridines
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Ion Channels
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Oxadiazoles
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Dimethylphenylpiperazinium Iodide
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Potassium
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Calcium
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Norepinephrine
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Epinephrine
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Isradipine