Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel

Brain Res. 1988 Jul 26;456(2):364-6. doi: 10.1016/0006-8993(88)90240-5.

Abstract

Dihydropyridines (+)-PN200-110 and (+/-)-Bay-K-8644 inhibit or potentiate, respectively, catecholamine release evoked by DMPP- or K-stimulation of perfused cat adrenal glands. Since both, secretion of adrenaline and noradrenaline are equally affected, and these two drugs specifically act on voltage-dependent chromaffin Ca channels, it seems that secretion of each amine from their respective cell is regulated by the same type of channel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
  • Adrenal Medulla / drug effects
  • Adrenal Medulla / metabolism*
  • Animals
  • Calcium / physiology*
  • Calcium Channel Blockers / pharmacology*
  • Cats
  • Dihydropyridines / pharmacology*
  • Dimethylphenylpiperazinium Iodide / pharmacology
  • Epinephrine / metabolism*
  • In Vitro Techniques
  • Ion Channels / drug effects
  • Ion Channels / physiology*
  • Isradipine
  • Norepinephrine / metabolism*
  • Oxadiazoles / pharmacology
  • Potassium / pharmacology
  • Reference Values

Substances

  • Calcium Channel Blockers
  • Dihydropyridines
  • Ion Channels
  • Oxadiazoles
  • Dimethylphenylpiperazinium Iodide
  • 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
  • Potassium
  • Calcium
  • Norepinephrine
  • Epinephrine
  • Isradipine