[Pathophysiological aspects of the diabetogenic effect of statins]

Ugeskr Laeger. 2014 Feb 3;176(3):223-7.
[Article in Danish]

Abstract

Statins are potent inhibitors of cholesterol biosynthesis. Statins are beneficial in the primary and secondary prevention of coronary heart disease. Recent studies indicate that there is an association between statin use and the development of new-onset diabetes mellitus. This article reviews the patophysiological mechanisms by different statins to explain this association.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Cardiovascular Diseases / drug therapy
  • Diabetes Mellitus / chemically induced*
  • Diabetes Mellitus / physiopathology
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / adverse effects
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / metabolism
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
  • Risk Factors

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors